Erectile dysfunction is the Critical disorder after premature ejaculation for sexual activity in men. Vardenafil hydrochloride (Referred as Levitra) as is an oral therapy for the treatment of erectile dysfunction. Vardenafil hydrochloride oral tablets have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance.
Dapoxetine hydrochloride (Referred as Priligy) was added to the best formulae of the prepared to treat premature ejaculation. The formulae were evaluated for weight variation, friability, drug content, in vitro disintegration time, wetting time, and the dissolution study.
Gelatin as a matrix former with N-methylpyrrolidone as a solubilizer improves the dissolution rate and extent of release of Vardenafil and Depoxetine with 100% of drug being dissolved after 15 min.
In research study results from six healthy male volunteers showed shorter Tmax of Vardenafil from Vardenafil & Depxitine solution of 0.583 ± 0.129 h and shorter Tmax of DH from Vardenafil & Depxitine solution of 0.625 ± 0.137 h and showed AUC0-12 of Vardenafil from VH/DH ODT of 39.234 ± 10.932 ng/ml h1 and AUC0-12 of DH from Vardenafil & Depxitine solution of 531.681 ± 129.544 ng/ml h1, with relative bioavailability values of 100.9 and 85%, respectively, compared to Vardenafil and Depoxetine.