Carbophage G1 Tablet PR

Carbophage G1 Tablet PR

Carbophage G1 Tablet contains 500mg of metformin and 1mg of glimepiride, making it a two-in-one medication. Its purpose is to assist individuals with type 2 diabetes in managing their blood sugar levels.

Complete Handbook on Carbophage G1 Tablet PR: Usage and Insight

MedicineCarbophage G1 Tablet PR
Marketed ByMerck Ltd
Active IngredientGlimepiride 1mg and Metformin 500mg
StorageStore below 30°C
Consume TypeOral 

Carbophage G1 Tablet PR – Introduction

Carbophage G1 Tablet PR offers a combination therapy for type 2 diabetes mellitus. This extended-release formulation combines glimepiride 1mg and metformin 500 mg, facilitating sustained blood sugar control when diet, exercise, and monotherapy prove inadequate. The dual mechanism of action enhances insulin secretion and sensitivity, promoting comprehensive diabetic management.

How Carbophage G1 Tablet PR Works: A Closer Look

Glimepiride (1mg):

This particular component belongs to the sulfonylurea class. Its mechanism of action involves stimulating the pancreatic beta cells, which in turn promotes the release of insulin in response to meals. Additionally, it improves the body’s ability to utilize insulin effectively.

Metformin (500mg):

Metformin (500mg) is a biguanide that works by reducing the liver’s production of glucose. It also improves insulin sensitivity in peripheral tissues such as muscles and fat, leading to better uptake and utilization of glucose.


In the management of Type 2 Diabetes Mellitus 

(In addition to diet and exercise, this medication helps enhance glycemic control in adults. It can be used if treatment with either Glimepiride or Metformin alone is not enough.)

Carbophage G1 Tablet PR – The Benefits 

  • Improved Glycemic Control:

Carbophage G1 Tablet combines glimepiride and metformin to offer a synergistic effect. This translates to superior blood sugar control compared to using either medication alone. The combined action of enhancing insulin secretion and sensitivity helps mitigate postprandial (after-meal) blood sugar spikes.

  • Convenient Dosing:

The extended-release formulation in glimepiride and metformin combination dosage allows for once-daily dosing, which can improve patient compliance and convenience. It also targets different aspects of diabetes pathophysiology, providing a comprehensive approach to diabetes management.

  • Cardiovascular Benefits:

Research suggests that metformin offers cardiovascular benefits, which can be particularly significant for diabetic patients with elevated cardiovascular risk.

  • Weight Neutral or Weight Loss:

Metformin is known to promote weight neutrality or modest weight loss, offering an advantage for overweight or obese patients with diabetes.

Carbophage G1 Tablet PR – A Usage Guide

  • Take the medication exactly as prescribed by your doctor. Do not alter or stop the prescribed glimepiride and metformin combination dosage without consulting your doctor. Usually taken once daily with the first main meal of the day (breakfast or dinner) to reduce the likelihood of gastrointestinal side effects.
  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break it. It is an extended-release formulation, and altering its form may affect the controlled release of the medication.

Carbophage G1 Tablet PR – Side Effects

Most adverse effects disappear when your body gets used to Carbophage G1 medication and doesn’t require medical attention. See your physician if they continue or if you have concerns about them.

Common Side Effects

  • Hypoglycemia (Low Blood Sugar)
  • Nausea and Vomiting
  • Diarrhea
  • Abdominal Pain and Bloating
  • Weight Gain
  • Edema (swelling)
  • Headache
  • Fatigue or Weakness
  • UTI

Rare but serious side effects may occur with metformin with glimepiride combination medicine, such as Lactic Acidosis, Allergic reactions, Hepatic Impairment, and Hemolytic Anemia. It is important to always notify your healthcare provider if you experience any side effects, particularly if they are severe or persistent. Your doctor might need to modify the dosage or recommend strategies for managing the side effects.

[Note: Various medications can lead to different side effects. For precise details about a particular drug’s specific side effects, consult the official prescribing information for that medication or seek advice from your healthcare provider.]


Carbophage G1 Tablet PR – A Guide to Safety




When using Carbophage G1 Tablet, it is important to avoid alcohol in order to prevent the occurrence of a dangerous condition called lactic acidosis, which involves the buildup of lactic acid in the body.



Consult Your Doctor

It may not be advisable to use during pregnancy. There is limited research on humans. However, studies on animals have shown adverse effects on fetal development. Your doctor will evaluate the benefits and potential risks before prescribing it.


  Breast feeding


It’s probably unsafe to use glimepiride 1mg and metformin 500mg medication while nursing. The baby could be adversely affected because the medication can pass into the breastmilk, based on the limited available information. It’s important to seek advice from your doctor.




If your blood sugar is too low or too high, it might impair your driving ability. If you experience these symptoms, refrain from driving.




Patients with liver disease should use the Carbophage G1 Tablet cautiously. They may require dose adjustment, so it’s important to consult with a doctor. In cases of mild to moderate liver disease, it’s typically initiated with a low dose, while it’s not advised for use in patients with severe liver disease.




People with kidney issues should be cautious when using it. Adjusting the medication dosage may be necessary. Please consult your doctor. However, Carbophage G1 Tablet PR is not recommended for those with severe kidney disease.


Fact Box

Chemical GroupBiguanide and Sulfonylurea class
Medication ClassBiguanide and ATP-sensitive potassium channel blocker
Action Class/CategoryAntihyperglycemic agent (Anti-Diabetic)

Swift Advice 

  • The medication should be taken in accordance with the doctor’s prescription, including the specified dose and duration. Monitor your blood sugar level regularly.
  • Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. glimepiride 1mg and metformin 500mg medication therapy may require modification or discontinuation during these life stages.
  • Report any weight gain, shortness of breath, irregular heartbeat, or unusual swelling to your doctor for prompt evaluation and potential treatment adjustments.
  • Take Carbophage G1 Tablet PR with the first main meal of the day to minimize gastrointestinal side effects and improve the medication’s effectiveness. Skipping meals can increase the risk of hypoglycemia, so eat regular, balanced meals.
  • Be mindful of the potential for hypoglycemia, particularly when combining Carbophage G1 Tablet with other diabetic medications, alcohol consumption, or missed meals. Symptoms may include cold sweats, cool and pale skin, tremors, and anxiety. It is recommended to carry sugary foods or juice in case of hypoglycemia to counteract a blood sugar drop.
  • Caution is advised if you have existing kidney or liver issues, as these conditions can impact the medication’s efficacy. Dosage adjustments may be necessary, as determined by your physician.

Frequently Asked Questions

Q: How does glimepiride metformin work?

A: Glimepiride and metformin work together to manage blood sugar levels in patients with type 2 diabetes. Glimepiride, a sulfonylurea, stimulates the pancreas to release more insulin in response to meals. Metformin, a biguanide, decreases the amount of glucose produced by the liver and improves insulin sensitivity, allowing the body to use insulin more effectively.

Q: Is glimepiride metformin effective for managing diabetes?

A: Yes, the combination of glimepiride and metformin is effective for managing type 2 diabetes. This combination provides a dual mechanism of action that helps control blood sugar levels more effectively than either drug alone. It is commonly prescribed when single-agent therapy does not achieve adequate glycemic control.

Q: How long does it take for glimepiride metformin to show results?

A: The effects of glimepiride and metformin can typically be observed within a few days to a few weeks. Patients may notice improvements in blood sugar levels relatively quickly, but it can take several weeks to achieve optimal control. Regular monitoring of blood glucose levels is important to assess the effectiveness of the medication.

Q: What organ is carbophage G1 hard on?

A: Carbophage G1, which contains metformin and glimepiride, can be hard on the kidneys. Metformin is primarily excreted by the kidneys, and impaired kidney function can increase the risk of lactic acidosis, a rare but serious side effect. Patients need to have their kidney function monitored regularly while taking this medication. Additionally, glimepiride may have some effects on the liver and pancreas.

Q: Where can I find a supplier for bulk Carbophage G1 Tablet?

A: The Lotus Biotech is a Global Exporter and Wholesale Trader of Anti-Diabetic Medicines. Buy the Carbophage G1 tablet at the best wholesale price and get it delivered faster. For more details, contact us at or +91 98998 96668.