Carbophage G2 Tablet PR

Carbophage G2 Tablet PR

Carbophage G2 Tablet is a two-in-one medication containing 500mg of metformin and 2mg of glimepiride. It helps people with type 2 diabetes control their blood sugar levels.

Complete Handbook on Carbophage G2 Tablet PR: Usage and Insight

MedicineCarbophage G2 Tablet PR
Marketed ByMerck Ltd
Active IngredientGlimepiride 2mg and Metformin 500mg
StorageStore below 30°C
Consume TypeOral 

Carbophage G2 Tablet PR – Introduction

Merck Ltd.’s Carbophage G2 Tablet PR offers a combination therapy for type 2 diabetes mellitus. This extended-release formulation combines glimepiride 2mg + metformin 500mg, facilitating sustained blood sugar control when diet, exercise, and monotherapy prove inadequate. The dual mechanism of action enhances insulin secretion and sensitivity, promoting comprehensive diabetic management.

How Carbophage G2 Tablet PR Works: A Closer Look

Glimepiride (2mg):

This component falls within the sulfonylurea class. Its mechanism of action involves stimulating pancreatic beta cells, thereby promoting insulin release in response to meals.  Furthermore, it enhances the body’s capacity to utilize insulin effectively.

Metformin (500mg):

Metformin (500mg): Classified as a biguanide, metformin’s primary function is to reduce the liver’s production of glucose. Additionally, it enhances insulin sensitivity within peripheral tissues like muscles and fat, leading to improved glucose uptake and utilization.


In the management of Type 2 Diabetes Mellitus

(In addition to diet and exercise, this medication helps enhance glycemic control in adults. It can be used if treatment with either Glimepiride or Metformin alone is not enough.)

Carbophage G2 Tablet PR – The Benefits 

  • Improved Glycemic Control:

Carbophage G2 Tablet combines metformin and glimepiride to offer a synergistic effect. This translates to superior blood sugar control compared to using either medication alone. The combined action of enhancing insulin secretion and sensitivity helps mitigate postprandial (after-meal) blood sugar spikes.

  • Convenient Dosing:

The extended-release formulation in glimepiride and metformin combination dosage allows for once-daily dosing, which can improve patient compliance and convenience. It also targets different aspects of diabetes pathophysiology, providing a comprehensive approach to diabetes management.

  • Cardiovascular Benefits:

Research suggests that metformin offers cardiovascular benefits, which can be particularly significant for diabetic patients with elevated cardiovascular risk.

  • Weight Neutral or Weight Loss:

Metformin is known to promote weight neutrality or modest weight loss, offering an advantage for overweight or obese patients with diabetes.

Carbophage G2 Tablet PR – A Usage Guide

  • Take the medication exactly as prescribed by your healthcare provider. Do not alter or stop the prescribed glimepiride and metformin combination dosage without consulting your doctor. Usually taken once daily with the first main meal of the day (breakfast or dinner) to reduce the likelihood of gastrointestinal side effects.
  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break it. It is an extended-release formulation, and altering its form may affect the controlled release of the medication.

Carbophage G2 Tablet PR – Side Effects

Most adverse effects disappear when your body gets used to Carbophage G2 Tablet and doesn’t require medical attention. See your physician if they continue or if you have concerns about them.

Common Side Effects

  • Hypoglycemia (Low Blood Sugar)
  • Nausea and Vomiting
  • Diarrhea
  • Abdominal Pain and Bloating
  • Weight Gain
  • Edema (swelling)
  • Headache
  • Fatigue or Weakness
  • UTI

Rare but serious side effects with glimepiride 2mg + metformin 500mg medicine such as Lactic Acidosis, Allergic reactions, Hepatic Impairment, and Hemolytic Anemia may occur. It is important to always notify your healthcare provider if you experience any side effects, particularly if they are severe or persistent. Your doctor might need to modify the dosage or recommend strategies for managing the side effects.

[Note: Various medications can lead to different side effects. For precise details about a particular drug’s specific side effects, consult the official prescribing information for that medication or seek advice from your healthcare provider.]


Carbophage G2 Tablet PR – A Guide to Safety




When using Carbophage G2 Tablet, it is important to avoid alcohol in order to prevent the occurrence of a dangerous condition called lactic acidosis, which involves the buildup of lactic acid in the body.



Consult Your Doctor

It may not be advisable to use during pregnancy. There is limited research on humans. However, studies on animals have shown adverse effects on fetal development. Your doctor will evaluate the benefits and potential risks before prescribing it.


  Breast feeding


It’s probably unsafe to use while nursing. The baby could be adversely affected because the medication can pass into the breastmilk, based on the limited available information. It’s important to seek advice from your doctor.




If your blood sugar is too low or too high, it might impair your driving ability. If you experience these symptoms, refrain from driving.




Patients with liver disease should use Carbophage G2 Tablet cautiously. They may require dose adjustment, so it’s important to consult with a doctor. In cases of mild to moderate liver disease, it’s typically initiated with a low dose, while it’s not advised for use in patients with severe liver disease.




People with kidney issues should be cautious when using it. Adjusting the medication dosage may be necessary. Please consult your doctor. However, Carbophage G2 Tablet PR is not recommended for those with severe kidney disease.

Fact Box

Chemical GroupBiguanide and Sulfonylurea class
Medication ClassBiguanide and ATP-sensitive potassium channel blocker
Action Class/CategoryAntihyperglycemic agent (Anti-Diabetic)

Swift Advice 

  • Take the medication exactly as your doctor prescribes, including the dose and duration.
  • Monitor your blood sugar level regularly.
  • Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. glimepiride 2mg + metformin 500mg medication therapy may require modification or discontinuation during these life stages.
  • Report any weight gain, shortness of breath, irregular heartbeat, or unusual swelling to your doctor for prompt evaluation and potential treatment adjustments.
  • Take Carbophage G2 Tablet PR with the first main meal of the day to minimize gastrointestinal side effects and improve the medication’s effectiveness. Skipping meals can increase the risk of hypoglycemia, so make sure to eat regular, balanced meals.
  • Be mindful of the potential for hypoglycemia, particularly when combining Carbophage G2 Tablet with other diabetic medications, alcohol consumption, or missed meals. Symptoms may include cold sweats, cool and pale skin, tremors, and anxiety. It is recommended to carry sugary foods or juice in case of hypoglycemia to counteract a blood sugar drop.
  • Caution is advised if you have existing kidney or liver issues, as these conditions can impact the medication’s efficacy. Dosage adjustments may be necessary, as determined by your physician.

Frequently Asked Questions

Q: What are the contraindications for metformin glimepiride?

A: Carbophage G2 Tablet is not recommended for everyone. Here are some instances where it should not be used:

  • If you have a known allergy to metformin, glimepiride, or similar medications.
  • If you have severe diabetic ketoacidosis (a complication of diabetes).
  • If you have severe kidney or liver problems.
  • If you are pregnant or breastfeeding.
  • If you have uncontrolled heart failure.
  • If you have a history of lactic acidosis (a buildup of lactic acid in the blood)

Q: Is glimepiride and metformin effective?

A: Yes, the combination of glimepiride and metformin in Carbophage G2 Tablet PR is an effective treatment for type 2 diabetes. It works by both increasing insulin production and improving your body’s sensitivity to insulin, leading to better blood sugar control.

Q: Does glimepiride and metformin lower blood sugar immediately?

A: No, glimepiride and metformin are not immediate-acting medications. The extended-release formulation of Carbophage G2 provides a gradual release of the medication throughout the day, helping to maintain stable blood sugar levels over time.

Q: Is Carbophage G2 used for anything other than diabetes?

A: No, Carbophage G2 Tablet PR is specifically designed to manage type 2 diabetes mellitus. It does not have any approved uses for other conditions.

Q: Where to buy Carbophafe G2 Tablet PR in bulk?

A: You can order medications combining metformin and glimepiride from The Lotus Biotech, a trusted supplier of pharmaceutical products in India. As an authorized Exporter & Supplier of Glimepiride Metformin Tablet, we offer competitive pricing. Reach out to us now for excellent deals!