Istamet 50/500mg Tablets

Istamet 50/500mg Tablets

Istamet, contains Sitagliptin and Metformin which tackles Type 2 diabetes by utilizing Sitagliptin to enhance insulin production and Metformin to reduce glucose production in the liver. This powerful combination targets the root causes of diabetes, promoting effective blood sugar management.

  • Manufactured By: Sun Pharma
  • Salt Composition:  Sitagliptin 500mg + Metformin 500mg


Istamet 50/500mg Tablets


Sun Pharma

Active Ingredient 

50mg Sitagliptin + 500mg metformin


Store below 30ᐤC

Consume Type 


Description – 

Complete Handbook on Istamet 50/500mg Tablets: Usage and Insight 

Istamet 50/500mg Tablets  – Introduction

Istamet 50/500 tablet is an antidiabetic medication that contains sitagliptin and metformin as a combination medicine that is recommended for patients with type 2 diabetes mellitus to control high blood sugar. Type 2 diabetes mellitus treatment reduces the risk of heart disease, kidney disease, stroke, blindness, and limb loss.

How Istamet 50/500mg Tablets Works: A Closer Look

Istamet 50/500mg Tablets is a medication that combines two active ingredients: Sitagliptin and Metformin. These chemical compounds are known for their antihyperglycemic properties, which means they help type II diabetes patients manage high blood sugar levels.

Sitagliptin is part of a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by inhibiting the DPP-4 enzyme, which in turn increases the levels of incretin hormones in the body. Incretins help regulate blood sugar levels by stimulating the release of insulin and reducing the production of glucagon after meals, thus lowering blood sugar.

Metformin belongs to the biguanide class of medications and is one of the most commonly prescribed oral medications for type 2 diabetes. It works primarily by reducing the amount of glucose produced by the liver and improving the body’s response to insulin, thereby increasing the uptake of glucose by cells for energy.

The combination of Sitagliptin and Metformin in Istamet 50/500mg Tablets acts in complementary ways to help control blood sugar levels. Sitagliptin helps regulate insulin and glucagon levels, while Metformin works on reducing the overall amount of glucose produced by the liver and improving the body’s insulin sensitivity.

 Istamet 50/500mg Tablets Use

  • Comprehensive Diabetes Management


Istamet 50/500mg Tablets – The Benefits 

Type 2 Diabetes melitus

Type II diabetes mellitus is a chronic medical condition that is characterized by abnormally high levels of glucose in the blood. It results from either insufficient body synthesis of the hormone insulin, which the pancreas produces to metabolize glucose, or from insufficient body cell sensitivity to insulin’s effects. Istamet 50/500mg Tablets offer dual benefits for Type 2 Diabetes mellitus. Combining Sitagliptin and Metformin, this medication helps regulate blood sugar levels. Sitagliptin works by increasing incretin hormones to stimulate insulin release and reduce blood sugar, while Metformin decreases liver glucose production and enhances insulin sensitivity. These combined actions assist in managing high blood sugar in Type 2 Diabetes, improving glycemic control, potentially reducing complications, and aiding overall diabetes management.

Istamet 50/500mg Tablets – A Usage Guide

Istamet 50/500mg Tablet is typically prescribed by healthcare professionals as part of a comprehensive treatment plan for individuals with type 2 diabetes. It’s important for patients to adhere to their prescribed dosage and follow their healthcare provider’s recommendations regarding diet, exercise, and other lifestyle modifications to manage their diabetes effectively. Regular monitoring of blood sugar levels and periodic check-ups are also commonly advised to ensure the medication’s efficacy and to manage any potential side effects.

Istamet 50/500mg Tablets – Side Effects

Most of the side effects usually subside when your body gets adjusted to this medicine, however, if these side effects persist for a longer period of time, kindly consult your doctor.

 Common Side Effects 

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Hypoglycemia (Low Blood Sugar)
  • Cough
  • Flatulence
  • Upper respiratory infections
  • Loss of appetite
  • Pain in extremities
  • Change in taste (Metallic taste)
  • Hypersensitivity reations
  • Lactic acidosis
  • Weakness or Fatigue
  • Pancreatitis
  • Skin redness/itchning
  • Drowsiness
  • Dry mouth

[Note: Different drugs can cause varying side effects. To get accurate information about a medication’s specific side effects, refer to the official prescribing information for that medication or consult with your healthcare provider.]

Istamet 50/500mg Tablets – A Guide to Safety 



Limit alcohol consumption while taking Istamet 50/500mg Tablets as it can affect blood sugar levels and increase the risk of side effects such as lactic acidosis. Alcohol intake should be moderated or avoided altogether, especially if you take this medication.


Consult Your Doctor 

Consult your doctor if you are pregnant or planning to become pregnant while using Istamet 50/500mg Tablets. While there might be a need for diabetes management during pregnancy, the risks and benefits of using this medication need to be evaluated by a healthcare professional.


Consult Your Doctor

It’s essential to discuss with your doctor before using Istamet 50/500mg Tablets if you’re a breastfeeding mother. The medication components may pass into breast milk, potentially affecting the infant. Your healthcare provider can guide you on the best course of action.



Istamet 50/500mg Tablets generally does not impair cognitive functions. However, it’s important to monitor your individual response to the medication. Low blood sugar levels (hypoglycemia) may affect concentration and coordination, so be cautious when driving or operating machinery.


Consult Your Doctor

If you have liver disease or a history of liver problems, your doctor should be informed. Istamet 50/500mg Tablets contain Metformin, which may require dosage adjustments or careful monitoring in individuals with liver conditions.


Consult Your Doctor

Individuals with kidney issues need careful monitoring while taking Istamet 50/500mg Tablets. Metformin, one of the components, can affect kidney function. Your doctor might adjust the dosage or choose an alternative treatment if necessary.

Drug interactions

  • ACE inhibitors
  • Sulfonylurea, Dichlorphenamide
  • NSAIDs
  • Cimetidine
  • Trimethoprim
  • Acetazolamide
  • Insulin
  • Iodinated contrast media
  • Gatifloxacin
  • Bexarotene
  • Anti-depressants
  • Drugs used for the treatment of glaucoma
  • Antibiotics
  • Anti-acidity drugs
  • Medicines that are taken for heart conditions
  • Anti-HIV drugs
  • Ethanol
  • Saliva-reducing drugs
  • Iodinated X-ray contrast agents
  • Anti-epileptic drugs
  • Sex hormones
  • Anti-oxidants
  • Anti TB drugs
  • Growth hormones

Fact Box

Chemical Group

Triazolopyrazine, biguanide



Medication Class

Antihyperglycemic combination drug

Action Class/Category

Biguanides, DPP-4 Inhibitors

Swift Advice 

  • Stay well-hydrated and maintain a consistent exercise routine.
  • To potentially minimize constipation, it’s advisable to consume this medication with meals. Should constipation persist, consider incorporating more fiber-rich foods such as fresh fruits and vegetables into your diet.
  • Take the tablet daily at a consistent time after eating to prevent potential stomach discomfort.
  • Regularly monitor your blood sugar levels while using this medication.
  • Keep chocolate, sugary foods, or juice on hand in case you experience symptoms of low blood sugar, like trembling hands or legs, perspiration, or unease.
  • Inform your doctor if you continually experience sickness or vomiting, encounter rapid breathing issues, or notice any other severe side effects.


Frequently Asked Questions – Istamet 50/500mg Tablets – 5 FAQs

Q1. 1. What actions should I take if I miss a dose of Istamet 50mg/500mg tablet?

A: If you forget to take Istamet 50mg/500mg tablet, take it when remembered. However, if it’s nearly time for your next dose, skip the missed one and resume your regular dosing schedule.

Q2. Are there specific dietary guidelines while using Istamet 50mg/500mg tablet?

A: Adhere to a balanced diet recommended by your healthcare provider while using Istamet 50mg/500mg tablet. Limit excessive alcohol intake, as it may elevate the risk of lactic acidosis.

Q3. How long does it take for Istamet 50mg/500mg tablet to exhibit its effects?

A: The onset of action can vary from person to person. Your healthcare provider can provide more details based on your individual condition.

Q4. What should I do if I encounter side effects following Istamet 50mg/500mg tablet intake?

A: If you undergo any side effects after using Istamet 50mg/500mg tablet, promptly consult your healthcare provider. They can assist in managing the side effects and may adjust your treatment plan if necessary.

Q5. Can I discontinue Istamet 50mg/500mg tablet if I feel improved?

A: Avoid discontinuing Istamet 50mg/500mg tablet without consulting your healthcare provider, even if you perceive improvement. Abruptly stopping the medication could result in a resurgence of elevated blood sugar levels.

Q6. Is Istamet 50mg/500mg tablet suitable for weight loss?

A: Istamet 50mg/500mg tablet is not primarily indicated for weight loss. However, some individuals may experience slight weight loss due to enhanced glycemic control.